SPRINGER TUMOR METABOLOME TARGETING AND DRUG DEVELOPMENT 2014 RETAIL EBOOK-kE

TITLE: TUMOR METABOLOME TARGETING AND DRUG DEVELOPMENT

PUBLISHER: SPRINGER LANGUAGE: ENGLISH

LINK: http://is.gd/IXjwjU RELEASE TYPE: RETAIL

FORMAT: PDF RELEASE DATE: 2014.03.09

ISBN: 9781461495451 STORE DATE: 2014

SAVED.MONEY: 119 EURO DISKCOUNT: 01 x 05MB

AUTHOR: KANNER, STEVEN (ED.)



BOOK



In this volume, the major metabolic alterations identified in

cancer and tumor-associated cells are explored, including

discussions of former and emerging approaches to drug development

in targeting cancer cell metabolism



The metabolic network in cells promotes the generation of both

energy and biomass needed for them to grow, divide and

differentiate. However, the metabolism of malignant cells

generally varies from that of normal cells. These differences

provide a platform for the discovery of new approaches to

targeting potential vulnerabilities in cancer cells for

therapeutic options Some of the significant changes that occur

involve ATP production and consumption that modulates the ATP to

ADP ratio, hypoxia and the effects of reactive oxygen species on

glycolysis, regulation of mitochondrial respiration, induction

and suppression of autophagy, and the Warburg effect and

"reverse" Warburg effect--these topics and more are discussed in

this volume