Barbara Migeon - Females Are Mosaics. X Inactivation and Sex Differences in Disease [2013][A]

Book Description
Publication Date: November 12, 2013
Women can be described as genetic mosaics because they have two distinctly different types of cells throughout their bodies. Unlike males, who have one X chromosome, females have two X chromosomes in every cell. Much has been written about the Y chromosome and its role in inducing maleness. This is the only book about the X chromosome as a key to female development and the role of X-related factors in the etiology of sex differences in human disease. This new edition reflects research advances from the six years since the widely praised first edition. New advances include knowledge of species differences in mammalian X inactivation processes and silencing of the inactive X chromosome.

Reviews
"This book provides a balanced overview of the field to date, allowing newcomers to the field to concentrate on the recent literature necessity...The information in the book is up-to-date and a superb introduction to the entire field for gradutate students and fellows."--Nature

"I thoroughly enjoyed reading this book...This important and enjoyable book should be read by physicians who care for women of all ages."--New England Journal of Medicine

"This book provides a balanced overview of the field to date, allowing newcomers to the field to concentrate on the recent literature necessity...The information in the book is up-to-date and a superb introduction to the entire field for gradutate students and fellows."--Nature

"I thoroughly enjoyed reading this book...This important and enjoyable book should be read by physicians who care for women of all ages."--New England Journal of Medicine"Migeons eyewitness account of the discovery of X inactivation and the investigations of its mechanism is engaging...Biologists will appreciate the breadth of the book and the thorough referencing."--Science

"This is a magnificent discussion of the X chromosome function, mechanisms of expression, and the role of the X chromosome in embryogenesis and human pathology. Congratulations are due to Dr. Migeon for a job well done. This is a unique book with very few omissions. Reading it is a pleasure and the author adheres to her goals and provides unique information in a manner I have not seen before. This book has no comparison and I look forward to updated editions." --Doody's

About the Author
Barbara Migeon, MD, is Professor in the McKusick-Nathans Institute of Genetic Medicine and the Department of Pediatrics at the Johns Hopkins School of Medicine. She had fellowships in pediatrics, endocrinology and genetics and is board certified in pediatrics, biochemical genetics and cytogenetics. She was the founding director of the Hopkins PhD Program in Human Genetics. Her research has been focused on the molecular mechanisms of X inactivation in human cell and the clinical consequences of the single active X chromosome.